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目的:结合病历分析各种治疗慢性粒细胞白血病(CML)药物的特点,寻找适合基层医院应用的治疗方法。方法:本组CML病人26人,男18例,女8例,根据国内采用的诊断标准明确诊断,分别应用羟基脲,马利兰,甲异靛及合用α-干扰素治疗。结果:应用羟基脲治疗的患者中10例达血液学完全缓解,4例部分缓解,1例未缓解;应用马利兰治疗的有3例达到血液学完全缓解,2例部分缓解,1例未缓解;应用甲异靛治疗的2人均达部分缓解;加用α-干扰素治疗的3人生存期3~10年。结论:今后在CML病人的治疗中,应以达到细胞遗传学缓解为治疗目标,在目前基层医院条件下,首选干扰素加化学药物治疗。
OBJECTIVE: To analyze the characteristics of various kinds of CML drugs in combination with medical records, and to find a suitable treatment method for primary hospital. Methods: Twenty-six CML patients, 18 males and 8 females, were diagnosed according to the diagnostic criteria adopted in China and were treated with hydroxyurea, melillamine, mechlorethamine, and interferon alfa. Results: Among the patients treated with hydroxyurea, hematologic complete remission was achieved in 10 cases, partial remission in 4 cases and unresponsiveness in 1 case. In 3 cases treated with melitrin, hematological complete remission was achieved, 2 cases partially remitted, and 1 case did not relieve. 2 cases were treated with methyl isoindole partial remission; plus α-interferon treatment of 3-year survival of 3 to 10 years. Conclusion: In the future treatment of patients with CML should be to achieve cytogenetic remission as the treatment goal in the current primary hospital conditions, the preferred interferon plus chemical treatment.