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1例55岁女性因腰椎间盘突出症口服尼美舒利0.1 g,2次/d治疗。患者既往无肝病史。连续服药20 d后出现上腹部胀痛、恶心、纳差。肝功能检测:ALT377 U/L,AST105 U/L,TBil 13.72μmol/L。乙肝表面抗原、甲肝抗体、丙肝抗体和戊肝抗体检测均为阴性。B超发现腹水,行腹腔穿刺抽出黄色浑浊液体180 ml,常规检查示:白细胞数1 720×106/L,李凡他试验(+)。停用尼美舒利,给予多烯磷脂酰胆碱、复方甘草酸苷、葡醛内酯及左氧氟沙星治疗。入院第10天患者腹水消失,之后肝功能逐渐好转出院;出院2个月后肝功能恢复正常。
A 55-year-old woman was treated with nimesulide 0.1 g twice daily for lumbar disc herniation. Past history of patients without liver disease. After 20 consecutive days of upper abdomen pain, nausea, anorexia. Liver function tests: ALT377U / L, AST105U / L, TBil13.72μmol / L. Hepatitis B surface antigen, hepatitis A antibody, hepatitis C antibody and hepatitis E antibody test were negative. B-ascites was found, paracentesis and out of the yellow cloudy liquid 180 ml, routine examination showed: leukocyte count 1 720 × 106 / L, Li where he test (+). Nimesulide was discontinued and polyene phosphatidylcholine, compound glycyrrhizin, glucurolactone and levofloxacin were given. On the 10th day after admission, the ascites disappeared, and the liver function gradually improved after discharge. After 2 months of discharge, the liver function returned to normal.