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目的:探讨复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛的临床疗效。方法:选取2013年6月—2015年12月鄂州市中医医院收治的冠心病心绞痛患者164例作为研究对象,以信封抽签法随机分为观察组和对照组各82例。对照组患者给予单硝酸异山梨酯治疗,观察组患者给予单硝酸异山梨酯联合复方丹参滴丸治疗。观察2组患者的临床疗效,比较2组患者的生活质量评分、总胆固醇水平、三酰甘油水平、每周心绞痛发作次数及每次心绞痛持续时间、不良反应发生率。结果:观察组患者的总有效率为95.12%(78/82),显著高于对照组的70.73%(58/82),差异有统计学意义(P<0.05);治疗后,观察组患者的生活质量评分显著高于对照组,观察组患者总胆固醇水平、三酰甘油水平显著低于对照组,观察组患者每周心绞痛发作次数及每次心绞痛持续时间显著低于对照组,差异均有统计学意义(P<0.05);2组患者的不良反应发生率的差异无统计学意义(P>0.05)。结论:复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛,疗效显著,能有效改善患者生活质量。
Objective: To investigate the clinical efficacy of compound Danshen dripping pills and isosorbide mononitrate in the treatment of angina pectoris. Methods: A total of 164 patients with coronary heart disease and angina pectoris admitted to Ezhou TCM Hospital from June 2013 to December 2015 were enrolled in this study. Each group was randomly divided into observation group (n = 82) and control group (n = 82) by lottery. Patients in the control group were given isosorbide mononitrate. Patients in the observation group were given isosorbide mononitrate combined with compound Danshen dropping pills. The clinical efficacy of two groups of patients was observed. The quality of life score, total cholesterol level, triglyceride level, the number of angina attacks per week and the duration of each angina pectoris, the incidence of adverse reactions were compared between the two groups. Results: The total effective rate of the observation group was 95.12% (78/82), significantly higher than that of the control group (70.73%, 58/82), the difference was statistically significant (P <0.05). After treatment, the patients in the observation group The quality of life score was significantly higher than the control group, the observation group patients with total cholesterol levels, triglyceride levels were significantly lower than the control group, the observation group patients with weekly angina pectoris episodes and each angina duration was significantly lower than the control group, the differences were statistically (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Compound Danshen dripping pills combined with isosorbide mononitrate in the treatment of angina pectoris have significant curative effect, which can effectively improve the quality of life of patients.