目的探讨血液灌流联合血液透析对维持性血液透析患者钙磷代谢指标的影响。方法选择2014年1月-2016年1月本院进行血液透析的98例患者作为研究对象,按照数字随机法分为对照组和观察组,每组49例。其中对照组患者进行血液透析治疗,观察组患者进行血液灌流与血液透析的联合治疗,比较两组患者治疗效果及钙磷代谢指标。结果观察组患者血清中钙、磷以及钙磷乘积和甲状旁腺素(i PTH)等指标均显著优于对照组;观察组患者皮肤瘙痒的视觉模拟评分<7分48例,占97.96%,显著多于对照组(42例、85.71%);以上差异均有统计学意义(均P<0.05)。结论血液灌流联合血液透析对维持性血液透析患者的钙磷代谢指标影响较小,可降低钙磷代谢紊乱的发生率,减少患者的皮肤瘙痒感,安全性高,实用性强,值得临床推荐。 Objective To investigate the effects of hemoperfusion combined with hemodialysis on calcium and phosphorus metabolism in maintenance hemodialysis patients. Methods A total of 98 patients undergoing hemodialysis in our hospital from January 2014 to January 2016 were selected as study subjects and divided into control group and observation group according to the digital randomization method, with 49 cases in each group. The patients in the control group were treated with hemodialysis. The patients in the observation group were treated with hemoperfusion and hemodialysis. The therapeutic effects and the indexes of calcium and phosphorus metabolism were compared between the two groups. Results The serum calcium, phosphorus, calcium and phosphorus products and parathyroid hormone (i PTH) in the observation group were significantly better than those in the control group. The visual analogue scale of pruritus in the observation group was less than 7/48 (97.96%), Significantly more than the control group (42 cases, 85.71%); the above differences were statistically significant (all P <0.05). Conclusion Hemoperfusion combined with hemodialysis on maintenance hemodialysis patients with less impact on indicators of calcium and phosphorus metabolism, can reduce the incidence of metabolic disorders calcium and reduce skin pruritus in patients with high safety, practicality, it is worth recommending.