为了解肝手术后肝昏迷等并发症的发生机制，阻断猪肝门４５ｍｉｎ后松钳６０ｍｉｎ，造成肠瘀血动物模型；观察小肠粘膜的变化，并检测血中肠源性毒物。结果发现：肝门阻断后血中组织蛋白酶Ｄ，内毒素及乳酸明显增高，且肠粘膜出现明显损伤。提示肝手术后并发症的发生与上述结果有关，在肝脏手术中保护肠道功能及其完整性尤有必要 To understand the mechanism of hepatic coma and other complications after liver surgery, blocking the porcine liver door 45min after the pincer clamp 60min, resulting in animal model of intestinal bleeding; observed small intestinal mucosal changes, and detection of blood-derived intestinal toxic substances. The results showed that hepatic portal vein cathepsin D, endotoxin and lactic acid were significantly increased, and obvious intestinal mucosa injury. Prompted the occurrence of complications after liver surgery and the above results, the protection of intestinal function and its integrity in liver surgery is particularly necessary