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目的 研究急性心肌梗死 (AMI)病人血清肌钙蛋白T(TnT)的动态变化及其与AMI近期预后的相关性。方法 采用ELISA方法测定 5 6例AMI病人胸痛发作后 0～ 16 8h不同时段和 6 0例不稳定心绞痛 (UAP)病人及 6 0例健康人血清TnT水平及其动态变化 ,并观察住院期间心脏事件和并发症发生情况。结果 (1)AMI病人TnT水平明显高于UAP组及健康对照组。 (2 )AMI时TnT释放呈两种曲线特征 ,其中Ⅰ组 (TnT1峰 / 2峰>1)的AMI并发症的发生率明显低于Ⅱ组 (TnT1峰 / 2峰≤ 1或TnT呈单峰曲线 ) (P <0 0 5 )。 (3)AMI组TnT峰值水平与CK -MB峰值水平呈显著正相关 (r =0 71,P <0 0 1)。结论 TnT是反映心肌损伤的较灵敏、特异的指标 ,与AMI并发症的发生有明显的相关性 ,可较准确地评估AMI近期预后的情况。
Objective To study the dynamic changes of serum troponin T (TnT) in patients with acute myocardial infarction (AMI) and its correlation with the recent prognosis of AMI. Methods Serum levels of TnT and its dynamic changes were measured in 60 AMI patients with AMI at 0-16h and 60 patients with unstable angina pectoris (UAP) and 60 healthy controls by ELISA. The cardiac events And complications occurred. Results (1) The TnT level in patients with AMI was significantly higher than that in UAP group and healthy control group. (2) TnT release in AMI showed two kinds of curve characteristics. The incidence of AMI complications in group Ⅰ (TnT1 peak / 2 peak> 1) was significantly lower than that in group Ⅱ (TnT1 peak / 2 peak ≤ 1 or TnT was single peak Curve) (P <0 05). (3) The peak level of TnT in AMI group was positively correlated with the peak level of CK-MB (r = 0 71, P <0.01). Conclusion TnT is a sensitive and specific indicator of myocardial injury. It has a significant correlation with the occurrence of AMI and can be used to evaluate the recent prognosis of AMI.