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目的 :观察金熊胆安胶囊对实验性豚鼠胆色素结石的溶石作用及机制。方法 :用致石饲料诱发豚鼠胆石模型后 ,予以金熊胆安胶囊混悬液灌胃治疗 ,疗程结束后 ,检测胆汁中总胆红素、间接胆红素、钙离子 (Ca2 + )含量及 β 葡萄糖醛酸酶活性 ,分别用重氮法、甲基麝香草酚蓝比色法和石井畅法测定。结果 :金熊胆安胶囊有较好地降低胆汁中总胆红素、间接胆红素、Ca2 + 浓度及 β 葡萄糖醛酸酶活性的作用。结论 :金熊胆安胶囊有较好的溶石作用 ,其机制与改善致石胆汁、恢复胆囊动力学环境有关。
Objective : To observe the effect and mechanism of Jinxiongdan’an Capsule on stone dissolution of gallstone pigment in experimental guinea pigs. METHODS: After guinea pig gallstone model was induced by quarry feed, Jin Xiong Dan An capsule suspension was intragastrically administered. At the end of the treatment period, total bilirubin, indirect bilirubin, and calcium ion (Ca2 +) were measured. The activity of β glucuronidase was measured using diazo method, methylthymol blue colorimetry and Ishii Chang method, respectively. Results : Jinxiong Dian Capsule can reduce the total bilirubin, indirect bilirubin, Ca2 + concentration and β glucuronidase activity in bile. Conclusion : Jinxiongdan’an Capsule has better effect of dissolving stone. The mechanism is related to improving the gallstone bile and restoring the dynamic environment of the gallbladder.