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Oct-4(POU5F1)为POU同源结构域转录因子家族中的一个成员,以往的证据表明Oct-4只在小鼠和人类胚胎干细胞(embryonic stem cell,ES细胞)、胚胎生殖细胞和胚胎/生殖细胞肿瘤中阳性表达,是胚胎干细胞自我更新的关键调节因子,对ES细胞全能性和未分化状态的维持具有重要的作用。然而
Oct-4 (POU5F1) is a member of the family of POU homeobox transcription factors and past evidence indicates that Oct-4 is expressed only in mouse and human embryonic stem cells (ES cells), embryonic germ cells and embryonic / Positive expression in germ cell tumors is a key regulator of ES cell self-renewal and plays an important role in the maintenance of pluripotency and undifferentiated ES cells. however