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目的:研究自身免疫性肝炎的中医证候分布规律及用药规律,为中医药定性定量治疗自身免疫性肝炎提供客观依据。方法:检索相关数据库,收集近20年来有关中医药治疗自身免疫性肝炎的相关临床研究报告,应用SPASS 17.0软件统计自身免疫性肝炎相关证候、治则出现的频次、频率以及药物的名称、种类、出现的频次、频率等。结果:共纳入文献47篇,781人,女性为主,年龄多分布在40~70岁。共整理出7个基本证型,根据频率由大到小依次为肝气郁结证、肝肾阴虚证、血瘀证、湿热蕴结证、气阴两虚证、脾肾阳虚证、肝阴虚证。治则治法方面按照频次排在前三位的分别是疏肝健脾、补益肝肾、清利湿热。文献中涉及中药共132味,药物出现总频次为12 216次,排在前5位的药物分别是白芍、柴胡、牡丹皮、生地黄、茯苓,涉及的药物种类共39种,主要以补气药、活血调经药、补血药、行气药为主。结论:自身免疫性肝炎多见于女性,中老年多发,以肝气郁结证为主,同时也有因气虚、阴虚、血虚、瘀血、湿热等因素的影响而发病者,本虚标实,治疗上以疏肝健脾为主,同时补益肝肾、行气活血、清热利湿等法也为治疗本病的常见方法。
Objective: To study the distribution pattern of TCM syndromes and medication rules of autoimmune hepatitis, and provide an objective basis for the qualitative and quantitative treatment of autoimmune hepatitis in TCM. Methods: We searched relevant databases and collected relevant clinical research reports on Chinese medicine treatment of autoimmune hepatitis in the past 20 years. We used SPASS 17.0 software to analyze the relevant syndromes of autoimmune hepatitis, the frequency and frequency of treatment and the names and types of drugs , The frequency of occurrence, frequency and so on. Results: A total of 47 articles were included in the literature, 781 were female and the majority were aged 40-70 years old. A total of seven basic syndromes sorted out, according to the frequency of descending order of liver qi stagnation syndrome, liver and kidney yin deficiency syndrome, blood stasis syndrome, damp heat syndrome, qi and yin deficiency, spleen and kidney yang deficiency, liver yin Deficiency card. Governance rule of law in accordance with the frequency of the top three are the Shuganjianpi, replenishing liver and kidney, clearing heat. There are 132 Chinese medicines involved in the literature, with a total frequency of 12 216 drugs. The top 5 drugs are white peony root, Bupleurum root, Cortex Moutan, Rehmannia glutinosa, Poria cocos, 39 kinds of drugs involved, Qi medicine, blood Tiaojing drugs, blood medicine, qi medicine. Conclusion: Autoimmune hepatitis more common in women, middle-aged and elderly multiple, with liver qi stagnation card based, but also due to Qi, Yin deficiency, blood deficiency, blood stasis, damp-heat and other factors and the incidence of patients, On the spleen-based Shugan, at the same time tonic liver and kidney, qi and activating blood, heat and dampness and other methods for the treatment of this disease is a common method.