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目的:研究美沙拉嗪联合中药保留灌肠治疗溃疡性结肠炎的临床效果。方法:将116例溃疡性结肠炎患者随机分为对照组和研究组各58例,对照组患者口服美沙拉嗪胶囊治疗,研究组患者在此基础上联合中药保留灌肠治疗,比较两组患者的临床疗效、不良反应发生率、黏膜组织变化情况。结果:经过治疗,研究组患者总有效率(98.28%)显著高于对照组(75.86%),组间临床疗效比较差异具有统计学意义(P<0.05);研究组患者黏膜组织总改善率明显高于对照组,差异具有统计学意义(P<0.05)。研究组患者不良反应发生率为6.90%。显著低于对照组的15.52%,差异具有统计学意义(P<0.05)。结论:美沙拉嗪联合中药保留灌肠治疗溃疡性结肠炎临床疗效显著,可有效改善患者腹痛、腹泻症状,值得临床推广应用。
Objective: To study the clinical efficacy of mesalazine combined with traditional Chinese medicine retention enema in the treatment of ulcerative colitis. Methods: A total of 116 patients with ulcerative colitis were randomly divided into control group and study group, 58 cases in each group. Patients in the control group were treated with mesalazine capsules. The patients in the study group were treated with retention enema on the basis of traditional Chinese medicine. Clinical efficacy, adverse reactions, mucosal changes. Results: After treatment, the total effective rate (98.28%) in the study group was significantly higher than that in the control group (75.86%), the difference in clinical efficacy was statistically significant (P <0.05); the total improvement rate of mucosal tissue in the study group was significantly Higher than the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in study group was 6.90%. Significantly lower than 15.52% of the control group, the difference was statistically significant (P <0.05). Conclusion: Mesalazine combined with traditional Chinese medicine retention enema has significant clinical curative effect on ulcerative colitis, which can effectively improve the symptoms of patients with abdominal pain and diarrhea, and is worthy of clinical application.