本文观察了大骨节病区患儿、非患儿和非病区儿童的尿羟脯氨酸和氨基多糖组分的排泄量与尿硒水平的关系,结果表明患儿的尿硒、羟脯氨酸和氨基多糖排泄量不仅低于非病区儿童,也低于病区非患儿,当尿硒低于2.00μg/24h时,硒对尿软骨代谢指标有显著影响,高于2.00μg/24h时,则与上述指标无明显相关关系。这些结果说明,病区儿童的低硒状态是导致软骨代谢异常的重要因素之一。 This article observed the relationship between urinary hydroxyproline and aminopolysaccharide excretion and urinary selenium levels in children with Kashin-Beck disease, non-children and non-ward children, the results showed that children with urinary selenium, hydroxyproline Acid and amino polysaccharide excretion was not only lower than non-ward children, but also lower than non-sick children. When urinary selenium was less than 2.00μg / 24h, selenium had a significant effect on urinary cartilage metabolic index, higher than 2.00μg / 24h When compared with the above indicators no significant correlation. These results indicate that children with low selenium status of the ward is one of the important factors that lead to abnormal cartilage metabolism.