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目的探讨铝碳酸镁咀嚼片联合Hp根治疗法治疗Hp阳性胃溃疡患者的疗效及1年复发情况。方法观察171例经胃镜证实的Hp阳性胃溃疡患者,随机分铝碳酸镁组93例,对照组78例,二组:笫1周均给克拉霉素500 mg+奥美拉唑20 mg,B id,阿莫西林500 mg+丽珠得乐1 000 mg,Tid,笫2~4周均给奥美拉唑20 mg,B id,第5~8周给奥美拉唑20mg,qd,均口服,治疗组:1~8周同时给铝碳酸镁1 000 mg,Tid,口服。结果治疗组治疗一天后腹痛等症状缓解优于对照组,治疗8周后二组内镜下观察溃疡愈合的无统计学差异,溃疡痊愈(Sc期)例数治疗组65例,对照组40例(P<0.05),显效例数治疗组18例中Sb期11例,对照组16例中Sb期5例,1年复查内镜治疗组内镜随访89例,复发2例,复发率2.24%,对照组随访76例,复发6例,复发率7.89%(P<0.05)。结论铝碳酸镁能保护胃粘膜,提高溃疡愈合质量,降低胃溃疡复发率。
Objective To investigate the curative effect and recurrence of Hp-positive gastric ulcer patients treated with aluminum magnesium carbonate chewable tablets combined with Hp root therapy. Methods 171 patients with Hp-positive gastric ulcer confirmed by gastroscopy were randomly divided into three groups: aluminum magnesium carbonate group (n = 93) and control group (n = 78). Two groups were given clarithromycin 500 mg plus omeprazole 20 mg , Amoxicillin 500 mg + Livzonde 1 000 mg, Tid, Zi 2 to 4 weeks were given omeprazole 20 mg, B id, the first 5 to 8 weeks to omeprazole 20mg, qd, are oral, Treatment group: 1 to 8 weeks while giving magnesium aluminum carbonate 1 000 mg, Tid, orally. Results After treatment for one day, the relief of abdominal pain and other symptoms in the treatment group was better than that in the control group. After 8 weeks of treatment, there was no significant difference between the two groups in the endoscopic observation of ulcer healing. The number of cases with ulcer healing (Sc stage) was 65 cases in the treatment group and 40 cases in the control group (P <0.05). There were 11 cases of Sb in 18 cases in treatment group, 5 cases in Sb group in 16 cases in control group and 89 cases in endoscopy group in 1 year. The recurrence rate was 2.24% In the control group, 76 cases were followed up and 6 cases relapsed. The recurrence rate was 7.89% (P <0.05). Conclusion Aluminum magnesium carbonate can protect the gastric mucosa, improve the quality of ulcer healing and reduce the recurrence rate of gastric ulcer.