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移植肾功能延迟最常见原因是急性肾小管坏死。环孢霉素(CsA)的肾毒性使移植肾功能延迟发生率增加、无尿期延长和降低移植肾存活率。鉴于CsA加重已受损肾脏的损害,早期的报导推荐,限制使用CsA,使用其它免疫抑制方法,直至移植肾功能恢复。而晚近报导指出,CsA对肾功能的损伤不一定会导致肾功能延迟(DGF)。为进一步明确有DGF的是否应该使用CsA,作者进行了随机的前瞻性研究,比较抗淋巴细胞球蛋白(ALG)和CsA对DGF的移植肾的作用。
The most common cause of delayed graft function is acute tubular necrosis. Cyclosporine (CsA) nephrotoxicity increased the delayed graft function, prolonged anuria, and decreased graft survival. Given CsA exacerbated damage to the damaged kidneys, early reports recommended limiting the use of CsA and using other immunosuppressive methods until the graft function recovered. Recently reported that CsA damage to renal function does not necessarily lead to delayed renal function (DGF). To further elucidate whether CsA should be used in patients with DGF, we conducted a prospective randomized prospective study comparing the effects of anti-lymphocyte globulin (ALG) and CsA on the DGF-grafted kidney.