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目的 :观察人胰岛素对 2型糖尿病口服降糖药控制不佳并有程度不等慢性并发症病人的疗效。方法 :58例(男 30例 ,女 2 8例 ) 2型糖尿病 ,年龄 48～ 79岁 ,平均年龄 54 5岁 ,病程 2个月～ 2 6年 ,平均 6 7年 ,应用人胰岛素每天 2 4～50U ,分早晚 2次 ,餐前 30min皮下注射 ,共观察 1 2周。结果 :治疗前后患者的空腹血糖 ,餐后 2h血糖 ,糖化血红蛋白均有明显下降 (P <0 0 1 ) ,药物副反应轻微 ,血压、血脂、肝功、肾功、心电图等指标较治疗前有不同程度改善。结论 :2型糖尿病同样存在胰岛素分泌不足 ,随着疾病的进展约 40～ 70 %的病人需要胰岛素后才能使血糖控制在比较理想的水平。本研究表明 ,2型糖尿病在口服降糖药不能很好控制血糖 ,且有不同程度的慢性并发症的情况下 ,应尽早改用人胰岛素治疗 ,使血糖控制在正常或接近正常水平 ,避免或延缓各种并发症的发生和发展 ,提高生活质量 ,延长寿命。
Objective: To observe the effect of human insulin on type 2 diabetes patients with poor control of oral hypoglycemic agents and varying degrees of chronic complications. Methods: 58 cases (30 males and 28 females) with type 2 diabetes mellitus, aged from 48 to 79 years, with an average age of 545 years and a course of 2 months to 26 years with an average of 67 years. ~ 50U, points morning and evening 2 times, subcutaneous injection 30min before meals, were observed 12 weeks. Results: Before and after treatment, the fasting blood glucose, postprandial 2h blood glucose and glycosylated hemoglobin were significantly decreased (P <0.01). The side effects of the drugs were mild. Blood pressure, blood lipids, liver function, renal function and electrocardiogram were significantly lower than those before treatment Different degrees of improvement. CONCLUSIONS: Type 2 diabetes also has insufficient insulin secretion. As the disease progresses, approximately 40-70% of patients require insulin to control their blood glucose levels more optimally. This study shows that type 2 diabetes in oral hypoglycemic agents can not be very good control of blood glucose, and varying degrees of chronic complications, the situation should be switched to human insulin as soon as possible to control blood glucose at normal or near normal levels, to avoid or Delay the occurrence and development of various complications, improve the quality of life and prolong life expectancy.