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目的:评价中国地区糖尿病对乳腺癌患者预后的影响,为临床工作提供依据。方法:检索万方、中国知网、维普、Medline、Pubmed、Embase数据库有关糖尿病对乳腺癌患者预后影响的文章,收集数据,进行meta分析,以合并OR值作为效应指标。结果:meta分析共纳入11篇文献,总共有28589个病例;合并糖尿病对乳腺癌患者5年无病生存率有影响[OR=2.48,95%CI(1.81~3.40);I2=0%,P(Q)=0.42];合并糖尿病对乳腺癌患者5年总生存率有影响[OR=2.40,95%CI(1.75~3.29);I2=81.67%,P(Q)<0.01]。结论:糖尿病对乳腺癌患者预后有影响,造成生存率降低。
Objective: To evaluate the influence of diabetes in China on the prognosis of patients with breast cancer and provide the basis for clinical work. Methods: The articles about the influence of diabetes on the prognosis of patients with breast cancer were collected from Wanfang, CNKI, VIP, Medline, Pubmed and Embase databases. The data were collected and analyzed by meta-analysis. The combined OR value was taken as the effect index. Results: A total of 11 articles were included in the meta-analysis. A total of 28589 cases were included in the meta-analysis. The 5-year disease-free survival rate of patients with breast cancer was significantly higher than that of the controls (OR = 2.48,95% CI 1.81-3.40) (Q = 0.42). The combined effect of diabetes on 5-year overall survival of patients with breast cancer [OR = 2.40,95% CI (1.75-3.32); I2 = 81.67%, P (Q) <0.01). Conclusion: Diabetes affects the prognosis of patients with breast cancer, resulting in lower survival rate.