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目的:观察脐带间充质干细胞辅助治疗难治性类风湿性关节炎的疗效和安全性。方法:将细胞总数为(5~7)×107个脐带间充质干细胞通过静脉输注途径移植到自愿接受干细胞移植的2例难治性类风湿性关节炎患者体内,4次为1个疗程,每次间隔1周。治疗后随访1年定期观察患者临床症状及各项生化和免疫学指标的变化并进行综合分析。结果:脐带间充质干细胞辅助治疗后1月余,2例患者的临床症状明显改善,28个关节的疾病活动度评分(DAS-28)由3.6和4.0分别降低为2.2和2.6,血沉、C反应蛋白水平和类风湿因子抗体滴度也较治疗前明显降低。随访1年余未观察到与治疗有关的副作用,并且症状持续缓解无复发。结论:脐带间充质干细胞辅助治疗可缓解难治性类风湿性关节炎的临床症状,且未观察到与治疗有关的副作用,安全性好,值得临床进一步研究其远期疗效。
Objective: To observe the efficacy and safety of umbilical cord mesenchymal stem cells in the treatment of refractory rheumatoid arthritis. Methods: The total number of cells (5 ~ 7) × 107 umbilical cord mesenchymal stem cells were transplanted to 2 refractory rheumatoid arthritis patients receiving stem cell transplantation by intravenous infusion, 4 times for one course of treatment , Every 1 week intervals. Followed up for 1 year after treatment regularly observed the clinical symptoms and biochemical and immunological indicators of changes and a comprehensive analysis. Results: The clinical symptoms of 2 patients were significantly improved after 1 month of umbilical cord mesenchymal stem cell-assisted therapy. The disease activity score (DAS-28) of 28 joints decreased from 3.6 and 4.0 to 2.2 and 2.6, respectively. Erythrocyte sedimentation rate Reactive protein levels and rheumatoid factor antibody titers were also significantly lower than before treatment. No side effects related to treatment were observed for more than one year of follow-up, and no recurrence of symptoms was sustained. Conclusion: The umbilical cord mesenchymal stem cells adjuvant therapy can alleviate the clinical symptoms of refractory rheumatoid arthritis, and no side effects associated with treatment are observed. It is safe and worthwhile to further study its long-term efficacy in clinic.