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目的探讨周围型肺癌体素内不相干运动弥散加权成像(IVIM-DWI)所得各参数与血管内皮生长因子(VEGF)阳性表达之间的相互关系。方法采用3.0T磁共振成像(MRI)前瞻性对66例周围型肺癌进行IVIM-DWI扫描,b值为0、5、10、15、20、25、50、80、150、300、500、800、1 000 s/mm,分别测量病灶实性部分的真实扩散系数(D)、灌注相关扩散系数(D*)、灌注分数(f值),同时对肺癌标本进行免疫组织化学检测VEGF的表达,然后将D、D*、f值与VEGF进行相关性分析。结果 66例周围型肺癌D值为(1.01±0.30)×10-3 mm/s,f值为(17±9)%,D*值为(14±9)×10-3 mm/s。周围型肺癌VEGF评分为(3.3±1.6)分,其f值与VEGF有相关性(r=0.273,P=0.035);D值、D*值与VEGF均无相关性(P=0.423、0.970)。结论周围型肺癌f值与VEGF表达呈正相关性,提示f值可提供周围型肺癌肿瘤血管生成的客观信息。
Objective To investigate the correlation between the parameters of vascular endothelial growth factor (VEGF) and the parameters of IVIM-DWI in peripheral lung cancer. Methods 66 cases of peripheral lung cancer were prospectively scanned by IVT with 3.0T magnetic resonance imaging (MRI). The b values were 0,5,10,15,20,25,50,80,150,300,500,800 , 1 000 s / mm. The real diffusion coefficient (D), perfusion-related diffusion coefficient (D *) and perfusion score (f value) of the real part of the lesion were measured. Meanwhile, the expression of VEGF was detected by immunohistochemistry in lung cancer specimens. Then D, D *, f value and VEGF correlation analysis. Results The values of D in 66 cases of peripheral lung cancer were (1.01 ± 0.30) × 10-3 mm / s, f (17 ± 9)% and D * (14 ± 9) × 10-3 mm / s. The VEGF score of peripheral lung cancer was (3.3 ± 1.6) points, the correlation between f value and VEGF (r = 0.273, P = 0.035). There was no correlation between D value and D * value with VEGF (P = 0.423,0.970) . Conclusion There is a positive correlation between f-value and VEGF expression in peripheral lung cancer, suggesting that f-value can provide objective information on angiogenesis in peripheral lung cancer.