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[目的]以非甾体抗炎药物阿司匹林复制大鼠胃溃疡复发的模型,观察溃疡平对大鼠胃溃疡复发的影响及抗复发机制。[方法]以Okabe乙酸涂抹法制作大鼠胃溃疡模型,用溃疡平治疗后灌服阿司匹林药液制作复发模型,测定溃疡指数、计算溃疡抑制率、复发率。[结果]溃疡平能明显降低溃疡复发率和溃疡指数,对大鼠乙酸胃溃疡具有抑制其发展的作用。[结论]溃疡平能提高溃疡愈合质量,降低阿司匹林所致的大鼠胃溃疡复发。
[Objective] To investigate the effect of ulcer on the recurrence of gastric ulcer in rats and the mechanism of anti-relapse by replicating the non-steroidal anti-inflammatory drug aspirin in the rat model of gastric ulcer recurrence. [Method] The model of gastric ulcer in rats was made by Okabe acetic acid smear method, the model of ulcer was treated with aspirin, then the ulcer index was calculated and the ulcer inhibition rate and recurrence rate were calculated. [Result] Ulcer was significantly reduced the recurrence rate of ulcer and ulcer index, and inhibited the development of gastric ulcer in rats. [Conclusion] Cushing ulcer can improve the quality of ulcer healing and reduce the recurrence of gastric ulcer caused by aspirin in rats.