明胶类血浆代用品是临床常用血容量扩充剂,但其扩容有效性和应用安全性问题长期存在。本文概述了血浆代用品历史演变和发展,从明胶活性肽与凝血功能/血容量间关系出发,对明胶血浆代用品导致凝血障碍的副作用和扩容有效性不足的可能改善途径进行了分析,并探讨了新型明胶修饰/交联剂的选择和明胶原料适用性。以期对新型明胶血浆代用品的研究和开发提供新方向和思路。 Gelatin-based plasma substitutes are clinically used blood volume extenders, but their expansiveness and safety implications have long existed. This article summarizes the historical evolution and development of plasma substitutes. Based on the relationship between gelatin active peptides and blood coagulation / blood volume, this paper analyzes the possible ways to reduce the side effects of coagulation disorders and the lack of effective expansion of gelatin plasma substitutes New Gelatin Modifier / Crosslinker Selection and Gelatin Raw Material Suitability. With a view to new gelatin plasma substitute research and development to provide new directions and ideas.