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目的探讨男性吸烟者急性心肌梗死(AMI)患者的冠状动脉硬化情况及早期血脂特点。方法将107例AMI患者按是否吸烟分为2组,吸烟组68例,非吸烟组39例,均行冠状动脉造影,以冠状动脉平均病变支数及Gensini积分,定量分析冠状动脉病变情况;检测入院后24 h内血脂水平,比较2组患者血脂水平差异。结果吸烟组冠状动脉平均病变支数、Gensini积分均高于非吸烟组,其中冠状动脉平均病变支数差异无统计学意义(P>0.05),Gensini积分差异有统计学意义(P<0.05);2组患者AMI早期,TG、载脂蛋白B(apo B)差异有统计学意义(P<0.05),总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(apo A)差异无统计学意义(P均>0.05)。结论男性吸烟者AMI冠状动脉硬化比非吸烟者严重,男性吸烟者AMI早期,除apoA及TG外,血脂水平与非吸烟者患者比较,差异无统计学意义。
Objective To investigate coronary atherosclerosis and early lipid profile in male smokers with acute myocardial infarction (AMI). Methods One hundred and seven patients with AMI were divided into two groups according to whether they smoked or not. Sixty-eight smokers and 39 non-smoking smokers were enrolled in this study. Coronary angiography was performed. The average number of coronary lesions and Gensini integral were used to analyze coronary lesions. Blood lipid levels within 24 h after admission were compared between the two groups of patients with lipid levels. Results The mean lesion count and Gensini score of coronary artery in smoking group were significantly higher than those in non - smoking group (P> 0.05). The difference of Gensini score was statistically significant (P <0.05). There were significant differences in the AMI, TG and apolipoprotein B between the two groups (P <0.05), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol LDL-C) and apolipoprotein A (P <0.05). Conclusions In male smokers, coronary atherosclerosis is more severe than in nonsmokers. There was no significant difference in serum lipids between nonsmokers and male smokers in the early stage of AMI except apoA and TG.