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目的探讨冠心病(CHD)患者经皮冠状动脉介入治疗(PCI)前后血清中血管内皮生长因子(VEGF)的变化及临床意义。方法选取CHD患者65例为观察组,分别于术前和术后检测外周血中VEGF水平,并与50例正常体检者进行对比。结果察组患者术前血清中VEGF表达明显高于对照组,术后即刻血清中VEGF迅速升高,术后24h和7d较术前明显下降,但仍明显高于对照组。在术后不同血运患者的比较中,术后24h和7d完全血运患者血清中VEGF明显低于不完全血运患者。结论血清VEGF水平可了解冠状动脉病变程度,而且还可作为CHD患者介入术后血运重建效果判断。
Objective To investigate the changes of serum vascular endothelial growth factor (VEGF) in patients with coronary heart disease (CHD) before and after percutaneous coronary intervention (PCI) and its clinical significance. Methods Sixty-five CHD patients were selected as the observation group. The levels of VEGF in the peripheral blood were measured before and after surgery, respectively, and compared with 50 normal subjects. Results The expression of VEGF in preoperative serum of patients in observation group was significantly higher than that in control group. The serum VEGF rapidly increased immediately after operation. The levels of VEGF decreased significantly at 24h and 7d after operation, but still significantly higher than those in control group. In the comparison of different blood donation patients after surgery, the serum VEGF in patients with complete blood supply at 24 and 7 days after operation was significantly lower than that in patients with incomplete blood supply. Conclusion The level of serum VEGF can understand the degree of coronary artery disease, but also can be used as CHD patients after interventional operation to determine the effect of revascularization.