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目的 :探讨糖尿病 (DM)作为老年性痴呆 (AD)危险因素的可能机理。方法 :放免法检测 DM组 5 8例 ,正常对照组33人的血浆 β-淀粉样蛋白 (Aβ)、雌二醇 (E2 )水平 ,DM组 2 6例脑 CT扫描。结果 :1 5例脑 CT皮质萎缩 ,脑室扩大。 DM组女性 E2 为 4 .4 6± 4 .31 pg/ml,对照组女性 E2 为 9.4 3± 7.87pg/ml,P<0 .0 1 ,两组有显著差异。DM组 Aβ为 5 8.37± 8.6 5 pg/m l,对照组 Aβ为 6 1 .1 5± 8.39pg/ml,两组无显著差异。结论 :DM作为 AD的危险因素的可能机理 :脑皮质萎缩 ;E2 水平显著降低 ;Aβ被晚期糖基化终末产物 (AGE)修饰后易沉积
Objective: To investigate the possible mechanism of diabetes mellitus (DM) as a risk factor for senile dementia (AD). Methods: Radioimmunoassay was used to detect the levels of plasma β-amyloid (Aβ) and estradiol (E2) in 58 patients in DM group and 33 in normal control group. Twenty-six patients underwent CT scan in DM group. Results: Fifteen cases of cerebral CT cortical atrophy, ventricular enlargement. The E2 level of women in DM group was 4.46 ± 4.31 pg / ml and that of female control group was 9.4 3 ± 7.87pg / ml, P <0.01, there was a significant difference between the two groups. The Aβ of the DM group was 5 8.37 ± 8.6 5 pg / ml, while that of the control group was 61.1 ± 8.39 pg / ml. There was no significant difference between the two groups. CONCLUSIONS: The possible mechanism of DM as a risk factor for AD is cortical atrophy and the level of E2 is significantly reduced. Aβ is easily modified by advanced glycation end products (AGE)