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日本大耳兔行盲肠结扎加穿孔（ＣＬＰ）造成腹腔感染致多器官功能障碍的动物模型，然后应用瑞典ＰＥＲＩＭＥＤ公司的新型４００１双通道激光多普勒血流仪动态测定应用大剂量山莨菪碱及地塞米松时，免耳及大腿肌肉内微循环的变化。结果发现，用药后实验兔耳微循环的灌注量及微循环内红细胞等移动的微粒数量和兔大腿肌肉内微循环的灌注量及微循环内红细胞等移动的微粒数量均有显著升高。结果表明静脉注射大剂量山莨菪碱及地塞米松能明显改善兔在多器官功能障碍时微循环的灌注。
Japanese large eared rabbit cecal ligation and perforation (CLP) caused by abdominal infection caused by multiple organ dysfunction in animal models, and then the application of the Swedish company PERIMED’s new 4001 dual-channel laser Doppler flow dynamic determination of high dose of anisodamine and Dexamethasone, the release of the ear and thigh muscle microcirculation changes. The results showed that the perfusion amount of microcirculation and the number of red blood cells moving in microcirculation and the microcirculation perfusion in rabbit thigh and the number of red blood cells moving in microcirculation were significantly increased after administration. The results show that intravenous injection of high-dose anisodamine and dexamethasone can significantly improve rabbit perfusion of microcirculation in multiple organ dysfunction.