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细胞周期是细胞生命活动的基本特征,完整的细胞周期受多种蛋白酶的调控,细胞周期调控失调与细胞癌变有着密切的关系.细胞周期蛋白依赖性激酶抑制剂(cyclin-dependent kinase inhibitors,CDKI)是以细胞周期蛋白依赖性激酶(cyclin-dependent kinases,CDKs)为靶点,通过阻断细胞周期控制细胞增殖,从而达到抗肿瘤的目的.简述了细胞周期、细胞周期蛋白依赖性激酶抑制剂、细胞周期调控机制与抗肿瘤作用之间的关系,综述了近年来具有嘌呤骨架的细胞周期蛋白依赖性激酶抑制剂的研究进展,并展望了其发展趋势.
Cell cycle is a basic feature of cell life activity. The intact cell cycle is regulated by many proteases, and the imbalance of cell cycle is closely related to cell carcinogenesis.Cyclyl-dependent kinase inhibitors (CDKI) Is a target of cyclin-dependent kinases (CDKs), which can inhibit tumor cell proliferation by blocking the cell cycle, so as to achieve the purpose of anti-tumor.The cell cycle, cyclin-dependent kinase inhibitor , The relationship between the cell cycle regulatory mechanism and anti-tumor effect, and reviewed the recent advances in purine cytoskeleton-dependent cyclin-dependent kinase inhibitors and its developmental trends.