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目的观察代偿期乙肝后肝硬化患者应用替比夫定联合安络化纤丸治疗后临床症状、体征、肝功能、血清肝纤维化指标的恢复情况和肝脏、脾脏影象学改变。方法将160例代偿期乙肝后肝硬化患者分为两组,治疗组80例患者口服替比夫定(0.6g/次,1次/d)、安络化纤丸(6g/次,2次/d);对照组80例接受丹参片治疗(3片/次,3次/d)。两组疗程均为6个月。结果替比犬定联合安络化纤丸治疗后血清透明质酸酶(HA)、层黏蛋白(LN)和Ⅲ型前胶原(PC-Ⅲ)平均水平下降十分显著,HA尤为突出;肝脏、脾脏影象学检查有显著改善。结论替比夫定联合安络化纤丸有较好的抗肝硬化效果。
Objective To observe the clinical symptoms, signs, liver function, serum liver fibrosis recovery and liver and spleen imaging changes in patients with decompensated hepatitis B after liver cirrhosis treated with telbivudine and Anluo Huanyu Pills. Methods 160 patients with decompensated hepatitis B cirrhosis were divided into two groups. Eighty patients in the treatment group were treated with telbivudine (0.6g / time, once daily), Anluo Huaxiang Wan (6g / time, twice daily / d); control group, 80 cases received Danshen tablets (3 tablets / time, 3 times / d). Two courses of treatment are 6 months. Results The average level of serum hyaluronidase (HA), laminin (LN) and type Ⅲ procollagen (PC-Ⅲ) decreased significantly with the combination of amphibian and Anluo Huanyu Pills. HA was especially prominent in the liver and spleen Image examination significantly improved. Conclusion The telbivudine combined with Anluo Huaxian Pills has good anti-liver cirrhosis effect.