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目的:观察低剂量吸入丙酸氟替卡松加口服补肾健脾冲剂治疗儿童慢性持续期哮喘的疗效。方法:107例患儿随机分为2组,分别用低剂量吸入丙酸氟替卡松(西药组)和加用补肾健脾冲剂口服(中西药结合组),3个月为1个疗程。观察2组患儿治疗后哮喘的控制情况、中医证候缓解情况、最大呼气峰流速、药物不良反应。结果:2组治疗1个疗程后哮喘症状明显好转,最大呼气峰流率增加量>30%,中西药结合组在改善患儿神疲纳呆、动则多汗、鼻塞流涕、易患感冒等方面,优于西药组,未发现不良反应。结论:低剂量吸入丙酸氟替卡松加补肾健脾冲剂口服可以减轻患儿气道变应性炎症,提高免疫功能,增强患儿及家长控制疾病的信心。
Objective: To observe the effect of low dose inhalation of fluticasone propionate plus oral administration of Bushen Jianpi granule on children with chronic persistent asthma. Methods: A total of 107 children were randomly divided into two groups. They were treated with low dose inhalation of fluticasone propionate (western medicine group) and Chinese herb of invigorating the kidney and invigorating the spleen (combined with traditional Chinese medicine and western medicine) respectively for 3 months. The asthma control, TCM symptom relief, maximal expiratory flow rate and adverse drug reactions were observed in two groups. Results: After 1 course of treatment, the symptoms of asthma in 2 groups were obviously improved, the maximal peak expiratory flow rate increased by more than 30%. The combination of Chinese and western medicine improved the children’s fatigue and fatigue, increased sweating, stuffy nose and runny nose, Flu and other aspects, better than Western medicine group, no adverse reactions were found. Conclusion: Low-dose inhalation of fluticasone propionate and nourishing kidney and invigorating the spleen granules can relieve airway allergic inflammation, improve immune function and enhance the confidence of children and parents in controlling diseases.