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目的 探讨肝细胞肝癌 (HCC)Survivin与血管内皮生长因子 (VEGF)的表达相关性及其临床意义。方法 应用链霉抗生物素蛋白 过氧化物酶免疫组织化学 (SP)法检测 5 6例HCC中Survivin与VEGF的表达。结果 HCC中 3 4例Survivin表达阳性 ,阳性率为 60 .7%。 3 5例VEGF表达阳性 ,阳性率为 62 .5 %。HCC组织Survivin与VEGF的表达阳性率高于癌旁组织及正常肝组织 (P <0 .0 5 )。Survivin的表达与HCC肿瘤镜下门静脉癌栓发生密切相关 (P <0 .0 5 )。VEGF的表达与HCC肿瘤大小、肿瘤镜下门静脉癌栓发生以及肿瘤病理分期密切相关 (P <0 .0 5 )。相关性检验示Survivin与VEGF之间有相关性 (χ2 =4.491,P <0 .0 5 )。结论 HCC中Survivin、VEGF蛋白表达均上调 ,共同参与HCC发生和发展 ,VEGF与Survivin有协同表达关系。
Objective To investigate the correlation between the expression of Survivin and vascular endothelial growth factor (VEGF) in hepatocellular carcinoma (HCC) and its clinical significance. Methods The expression of survivin and VEGF in 56 HCCs was detected by streptavidin peroxidase immunohistochemistry (SP method). Results Survivin was positive in 34 cases of HCC, the positive rate was 60.7%. 35 cases of VEGF expression was positive, the positive rate was 62.5%. The positive rates of Survivin and VEGF in HCC tissues were higher than those in paracancerous tissues and normal liver tissues (P <0.05). The expression of Survivin was closely related to the occurrence of portal vein tumor thrombus in HCC tumor (P <0.05). The expression of VEGF was closely related to the size of HCC, the incidence of tumorous portal vein thrombosis and the pathological stage of tumor (P <0.05). Correlation test showed a correlation between Survivin and VEGF (χ2 = 4.491, P <0.05). Conclusion The expressions of Survivin and VEGF in HCC are all up-regulated, and they are involved in the occurrence and development of HCC. The expression of VEGF and Survivin have a synergistic relationship.