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目的 探讨谷氨酰胺 (Gln)强化的TPN对胃肠道肿瘤术后病人营养状况及免疫功能的影响。方法 2 0例胃肠道肿瘤病人术后随机分为常规TPN组 (对照组 )和 (TPN +Gln)组 (研究组 ) ,治疗共 8d ,观察血清前白蛋白、血清转铁蛋白、氮平衡变化。并检测其前后外周血lgG、lgM、lgA、C3、C4的变化。 结果 (1)两组病人呈正氮平衡趋势 ,研究组与对照组比较差异明显 (P <0 .0 1)。两组病人血清蛋白均上升 ,研究组回升更明显 ,与对照组比较具有显著差异 (P <0 .0 1)。(2 )研究组外周血lgG、lgM、lgA明显升高 ,与对照组比较差异显著 (P <0 .0 5 )。研究组C3 、C4 明显升高与对照组比较差异显著 (P <0 .0 5 )。结论 Gln强化的TPN提高了肠外营养支持的效果 ,改善了胃肠道肿瘤术后的免疫功能。
Objective To investigate the effect of glutamine (Gln)-enhanced TPN on postoperative nutritional status and immune function of patients with gastrointestinal cancer. Methods Twenty patients with gastrointestinal cancer were randomly divided into conventional TPN group (control group) and (TPN + Gln) group (study group) for 8 days. Serum prealbumin, serum transferrin, and nitrogen balance were observed. Variety. The changes of lgG, lgM, lgA, C3, and C4 before and after peripheral blood were measured. Results (1) Positive balance of nitrogen was observed between the two groups of patients. There was a significant difference between the study group and the control group (P < 0.01). Serum protein levels in both groups increased, and the study group rebounded more significantly, with a significant difference compared with the control group (P < 0.01). (2) The lgG, lgM, and lgA levels in the peripheral blood of the study group were significantly higher than those in the control group (P < 0.05). The significant increase in C3 and C4 in the study group was significantly different from that in the control group (P < 0.05). Conclusion Gln-enhanced TPN improves the effectiveness of parenteral nutrition support and improves the immune function of post-operative gastrointestinal cancer.