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目的探讨高血压患者晨峰睡-谷值与血管紧张素Ⅱ(AngⅡ)、醛固酮(ALD)、生长激素(GH)、皮质醇(COR)之间的相关性。方法 306例高血压患者,依据晨峰变异>10 mm Hg(1 mm Hg=0.133 kPa)规定分为非晨峰组(214例)与晨峰组(92例),检测患者血液中的AngⅡ、ALD、GH、COR水平,分析高血压患者晨峰睡-谷值与血液中AngⅡ、ALD、GH、COR之间的关系。结果晨峰组患者AngⅡ(162.8±82.3)ng/(ml·h)、ALD(210.4±40.0)ρ/(pg·ml)、GH(3.8±1.9)ρ/(pg·ml)、COR(18.7±5.3)ρ/(ng·ml)显著高于非晨峰组的(137.8±73.9)ng/(ml·h)、(140.1±47.1)ρ/(pg·ml)、(1.4±0.7)ρ/(pg·ml)、(14.2±4.2)ρ/(ng·ml),两组数据比较差异有统计学意义(t=2.62、12.51、16.13、7.92,P<0.05)。晨峰组晨峰睡-谷值与AngⅡ、ALD、GH、COR呈正相关(r=0.43、0.27、0.46、0.33,P=<0.01或0.05)。结论高血压患者在晨间的血压升高与AngⅡ、ALD、GH、COR有着密切的关系。
Objective To investigate the relationship between morning sleep peak - trough and the levels of Ang Ⅱ, aldosterone (ALD), growth hormone (GH) and cortisol (COR) in hypertensive patients. Methods 306 patients with hypertension were divided into non-morning peak group (214 cases) and morning peak group (92 cases) according to the morning peak variation> 10 mm Hg (1 mm Hg = 0.133 kPa). The levels of AngⅡ, ALD, GH, COR levels, analysis of morning sickle sleep - trough in patients with hypertension and blood Ang Ⅱ, ALD, GH, COR relationship. Results Ang Ⅱ (162.8 ± 82.3) ng / (ml · h), ALD (210.4 ± 40.0) ρ / (pg · ml), GH (3.8 ± 1.9) ρ / (pg · ml) ± 5.3) ρ / (ng · ml) was significantly higher than that of non-morning peak (137.8 ± 73.9) ng / (ml · h), (140.1 ± 47.1) ρ / (pg · ml) (14.2 ± 4.2) p / (ng · ml), there was significant difference between the two groups (t = 2.62,12.51,16.13,7.92, P <0.05). There was a positive correlation between sleep-trough and AngⅡ, ALD, GH, COR (r = 0.43,0.27,0.46,0.33, P = <0.01 or 0.05). Conclusions The elevated blood pressure in patients with hypertension in the morning is closely related to Ang Ⅱ, ALD, GH and COR.