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目的探讨肺泡表面活性物质(PS)联合西地那非(SIL)和高频振荡通气(HFOV)治疗新生儿持续肺动脉高压(PPHN)的疗效。方法选取2013年6月—2015年6月在成都市妇女儿童中心医院新生儿科住院治疗并确诊PPHN患儿52例,根据治疗方法不同分为试验组(应用PS治疗)和对照组(未使用PS治疗),各26例。比较两组患儿的动脉血气分析指标〔动脉血氧分压(PO2),肺动脉压力(PAP)和吸氧分数(Fi O2)〕。结果治疗前两组患儿监测指标比较,差异无统计学意义(P>0.05);治疗后试验组PO2高于对照组,PCO2、Fi O2、PAP低于对照组,差异有统计学意义(P<0.05)。两组患儿均未发生严重不良反应。结论 PS联合SIL和HFOV治疗新生儿PPHN能快速缓解病情,有利于患儿预后。
Objective To investigate the efficacy of alveolar surfactant (PS) combined with sildenafil (SIL) and high frequency oscillatory ventilation (HFOV) in the treatment of neonatal persistent pulmonary hypertension (PPHN). Methods From June 2013 to June 2015, 52 children with PPHN were hospitalized and diagnosed in the Neonatology Center of Chengdu Women and Children’s Central Hospital. According to the different treatment methods, they were divided into experimental group (treated with PS) and control group (without PS Treatment), each 26 cases. Arterial blood gas analysis indices (PO2, PAP, and Fi O2) were compared between the two groups. Results Before treatment, there was no significant difference between the two groups (P> 0.05). After treatment, the PO2 in the experimental group was higher than that in the control group, while the PCO2, FiO2 and PAP were lower than the control group (P <0.05). No serious adverse reactions occurred in both groups. Conclusion PS combined with SIL and HFOV treatment of neonatal PPHN can quickly alleviate the condition, is conducive to the prognosis of children.