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目的探讨妊娠期高血压综合征孕产妇行血栓前状态凝血功能检测的临床意义。方法分别检测60例妊娠期高血压综合征孕产妇及100名健康妊娠妇女的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶-抗凝血酶III复合物(TAT)、D-二聚体(D-dimer),并进行相关对比、分析。结果重度妊娠期高血压综合征孕产妇PT、APTT则较健康妊娠妇女明显缩短,且差异有统计学意义(P<0.05);与健康妊娠妇女相比较,轻度、中度、重度妊娠期高血压综合征孕产妇FIB均明显升高,差异有统计学意义(P<0.05),且随病情加重呈逐渐递增趋势;中度、重度妊娠妇女TAT、D-dimer水平均明显高于对照组,且差异有统计学意义(P<0.05)。结论妊娠期高血压综合征孕产妇血液存在明显血栓前状态,血栓前状态凝血功能及时检测对妊娠期高血压综合征的预防、治疗均具有重要临床指导意义。
Objective To investigate the clinical significance of prethrombotic state coagulation tests in pregnant women with gestational hypertension. Methods The prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), thrombin - anticoagulant in 60 pregnant women with gestational hypertension syndrome and 100 healthy pregnant women were detected. Thrombin III complex (TAT) and D-dimer, and compared and analyzed. Results The PT and APTT of pregnant women with severe pregnancy-induced hypertension syndrome were significantly shorter than those of healthy pregnant women (P <0.05). Compared with healthy pregnant women, mild, moderate and severe gestational hypertension Blood pressure syndrome maternal FIB were significantly higher, the difference was statistically significant (P <0.05), and with the increase of the disease was gradually increasing trend; moderate and severe pregnancy women TAT, D-dimer levels were significantly higher than the control group, And the difference was statistically significant (P <0.05). Conclusion Pregnant women with Hypertension syndrome have obvious prethrombotic state of blood, and the prethrombotic state coagulation function test in time has the important clinical significance in the prevention and treatment of Hypertension syndrome.