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为探讨中成药乳康片对大鼠血浆雌二醇、孕酮和泌乳素含量的影响，采用外源性性激素复制乳腺增生动物模型，分别设置空白对照、药物对照、５倍、１０倍、２０倍治疗剂量乳康片组和ＴＡＭ组。实验３０天后果外周血放免法检测Ｅ２、Ｐ和ＰＲＬ。结果显示：１０倍乳康片组血浆Ｅ２值低于药物对照组和ＴＡＭ组（Ｐ＜０．０１，Ｐ＜０．０１）。１０倍和２０倍乳康片组Ｅ＿２值明显低于５倍组（Ｐ＜０．０１，Ｐ＜０．０１）．前两组间无显著差异。结果还显示乳康片存在对孕酮的影响。结论：乳康片有降低血浆Ｅ＿２的作用，且在作用过程中存在饱和现象。同时对孕酮有降低作用。１０倍乳康片为本实验最佳剂量。
To investigate the effects of Rukang Tablets on the levels of plasma estradiol, progesterone and prolactin in rats, exogenous hormones were used to replicate the model of mammary gland hyperplasia, and blank control, drug control, 5 times, 10 times, 20 times Times the therapeutic dose of milk Kang tablet group and TAM group. Peripheral blood was radioimmunoassayed for E2, P and PRL after 30 days of experiment. The results showed that the plasma E2 level of 10 times Rukang tablet group was lower than that of drug control group and TAM group (P <0.01, P <0.01). The values of E_2 in 10 times and 20 times of milkvetch tablets group were significantly lower than those in 5 times (P <0.01, P <0.01). No significant difference between the first two groups. The results also show that lactate tablets exist on the impact of progesterone. Conclusion: Rukang Tablets can reduce the plasma E_2, and there is saturation in the process. At the same time have a reduced effect on progesterone. 10 times the milk tablets for the best experimental dose.