论文部分内容阅读
目的探讨2型糖尿病患者血清高尿酸与心功能及血脂的关系。方法随机抽取331例2型糖尿病患者,其中男223例,女108例,分别检测血清尿素氮(BUN)、肌酐(Cr)、尿酸(UA)、甘油三酯(TG)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、葡萄糖(GLU)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C),依据尿酸水平将患者分为尿酸增高组和正常组。结果80例尿酸增高患者中,男性患者54例,发生心功能损害的比例为50%(27/54);女性患者26例,发生心功能损害的比例为42.31%(11/26),两组比较性别差异无统计学意义(χ2=0.15,P=0.70)。然而,在充分考虑性别因素后,分别比较男性和女性2型糖尿病患者,其中男性患者尿酸增高组与尿酸正常组各项心功能指标包括CK(P<0.01)、CK-MB(P<0.05)、LDH(P<0.01)差异均有统计学意义,但女性患者则未发现两组之间的心功能改变差异有统计学意义。男性尿酸增高患者尿酸水平与TC(r=-0.291,P<0.05)和TTG(r=-0.367,P<0.01)成负相关,尿酸正常患者其尿酸水平则与TC(r=0.175,P<0.05)成正相关,与TTG未发现明显相关性(r=0.060,P=0.436)。结论高尿酸在2型糖尿病患者中发生心功能损害起着重要作用,以男性患者尤为显著,而对血脂的影响则可能起着双向作用。
Objective To investigate the relationship between serum uric acid and cardiac function and blood lipids in type 2 diabetic patients. Methods A total of 331 patients with type 2 diabetes mellitus were enrolled. Among them, 223 were male and 108 were female. Serum urea nitrogen (BUN), creatinine (Cr), uric acid (UA), triglyceride (TG) and creatine kinase ), CK-MB, LDH, GLU, TC and HDL-C were calculated. Patients were divided according to uric acid level For uric acid increased group and normal group. Results Among the 80 patients with elevated uric acid, 54 cases were male and the incidence of cardiac dysfunction was 50% (27/54). Among 26 female patients, 42.31% (11/26) had cardiac dysfunction, There was no significant difference in gender (χ2 = 0.15, P = 0.70). However, after taking full account of gender, we compared male and female patients with type 2 diabetes mellitus. Among them, CK, MB and CK-MB were significantly higher in male patients with elevated uric acid and normal uric acid group (P <0.01) , LDH (P <0.01), but there was no significant difference in cardiac function between the two groups in female patients. The level of uric acid in male patients with elevated uric acid was negatively correlated with TC (r = -0.291, P <0.05) and TTG (r = -0.367, P <0.01) 0.05), but no significant correlation with TTG (r = 0.060, P = 0.436). Conclusions Hyperuricemia plays an important role in the development of cardiac dysfunction in patients with type 2 diabetes, especially in male patients, while the effect on blood lipids may play a bidirectional role.