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目的 :探讨甲状腺乳头状癌 CD44v6的表达与淋巴结转移的关系。方法 :应用免疫组化 SP法对 2 0例有颈淋巴结转移的甲状腺乳头状癌 ( PTC+LNM) ,3 0例无颈部淋巴结转移的甲状腺乳头状癌 ( PTC) ,10例甲状腺腺瘤 ( TA)和 10例正常甲状腺组织( NTT)进行了 CD44v6检测。结果 :PTC+L NM组的 CD44v6阳性率显著高于 PTC组 ,TA组和 NTT组者 ( P<0 .0 5 )。结论 :( 1)CD44v6的阳性表达与甲状腺乳头状癌的颈淋巴结转移密切相关 ,CD44v6有助于甲状腺乳头状癌的颈淋巴结转移。 ( 2 ) CD44v6可作为甲状腺乳头状癌较好的转移评估指标
Objective: To investigate the relationship between the expression of CD44v6 in papillary thyroid carcinoma and lymph node metastasis. Methods: Twenty cases of thyroid papillary carcinoma (PTC + LNM) with cervical lymph node metastasis, 30 cases of thyroid papillary carcinoma (PTC) without cervical lymph node metastasis and 10 cases of thyroid adenoma TA) and 10 cases of normal thyroid tissue (NTT) were detected CD44v6. Results: The positive rate of CD44v6 in PTC + L NM group was significantly higher than that in PTC group, TA group and NTT group (P <0.05). Conclusion: (1) The positive expression of CD44v6 is closely related to the cervical lymph node metastasis of thyroid papillary carcinoma. CD44v6 contributes to the cervical lymph node metastasis of papillary thyroid carcinoma. (2) CD44v6 can be used as a good indicator of thyroid papillary carcinoma metastasis