本文对原发性十二指肠恶性肿瘤28例进行临床分析,病变部位以乳头附近多见;病变类型主要为腺癌;主要临床表现为消瘦、贫血、上腹痛、出血、梗阻、黄疸,可伴有发热、腹块、穿孔,临床上缺乏特异性,常易误诊.手术切除肿瘤是本病唯一较好的治疗方法.本病早期诊断和治疗极为重要. This article clinical analysis of 28 cases of primary duodenal malignancies, the lesion site is more common near the nipple; lesion type is mainly adenocarcinoma; the main clinical manifestations of weight loss, anemia, upper abdominal pain, bleeding, obstruction, jaundice, can be With fever, abdominal mass, perforation, clinical lack of specificity, often misdiagnosed. Surgical removal of the tumor is the only good treatment for this disease. Early diagnosis and treatment of this disease is extremely important.