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农药敌枯双,化学名N-N′-甲撑-双(2-氨基-1、3、4-噻二唑),对大、小鼠胚胎发育的影响,国外有不少研究报告。近十年来国内学者也有一些论著。盛佩蒂等1984年用不同剂量的敌枯双煮沸水溶液对小白鼠胚胎毒性和致畸作用的研究中表明,采用200mg/kg剂量吸收胎少,致畸率较高。本实验按不同给药时间观察小鼠胚胎发育的影响,目的在于摸清不同给药时间所致畸形与器官发生时期的关系,为进一步研究药物解毒提供资料。材料和方法一、实验动物是本院动物场提供的小白鼠。雌鼠均为处女鼠,重量25～40g;雄鼠重30～35g。受试动物按照雌、雄2:1的比例过夜交配。每天上午8时、下午4时各
There are many research reports on the effects of pesticides, the enemy of the enemy, the chemical name N-N′-Methane-bis(2-amino-1,3,4-thiadiazole), on the development of large and mouse embryos. In the past ten years, domestic scholars also have some articles. Sheng Peidi et al. (1984) studied the embryotoxicity and teratogenicity of mice with different doses of bifenthrine boiled water in 1984. The results showed that 200 mg/kg dose absorbed fewer fetuses and the teratogenicity was higher. The purpose of this experiment was to observe the effects of mouse embryonic development at different administration times. The purpose was to find out the relationship between the malformations caused by different administration times and organogenesis times, and to provide information for further research on drug detoxification. Materials and Methods 1. Experimental animals are mice provided by our animal farm. Female mice were virgin mice weighing 25-40 g; male rats weighed 30-35 g. The test animals were mated overnight according to the female and male ratio of 2:1. Every day at 8 a.m. and 4 p.m.