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熊去氧胆酸系1929年在日本首次发现,用作利胆剂,以后又发现它与鹅去氧胆酸同样有溶解胆石作用,且每日剂量较低,无轻泻作用,无肝胆毒性。本院自1985年以来用国产熊去氧胆酸治疗胆囊结石38例,现分析如下:全组病例均经口服胆囊造影检查,25例为胆囊内负性结石,7例胆囊未显影,5例胆囊显影未见结石,一例慢性胆囊炎。后13例x线检查不能判定胆结石。但38例经B超检查均提示胆结石。用药后疗效如下: 1.38例中胆石消失2例,缩小减少13例,有效率为39.5%。2.结石大小与疗效:结石<5mm,有效率为33.3%,结石5～15mm,有效率为
Ursodeoxycholic acid was first discovered in Japan in 1929 as a choleretic agent, and later it was found to have the same effect of dissolving gallstone as chenodeoxycholic acid with a lower daily dose, no laxation and no hepatotoxicity . The hospital since 1985 with domestic ursodeoxycholic acid in the treatment of 38 cases of gallstone, are analyzed as follows: All patients were diagnosed by oral cholecystography, 25 cases of negative gallbladder stones, 7 cases of gallbladder undeveloped, 5 cases No gallstone gallstone, a case of chronic cholecystitis. After 13 cases of x-ray examination can not determine gallstones. However, 38 cases of B-ultrasound are prompted gallstones. After treatment, the efficacy is as follows: 1.38 cases of gallstone disappeared in 2 cases, reduced to reduce the 13 cases, the effective rate was 39.5%. 2. Stone size and efficacy: stones <5mm, the effective rate was 33.3%, stones 5 ~ 15mm, the effective rate was