Chronic kidney disease(CKD) and chronic liver disease are both very harmful to human health almost all over the world,which lead to the fibrosis of the two organs ultimately.Currently,there are few satisfactory therapeutic methods in treating the two diseases.Some research works from Chinese medicine and Western medicine were done in the area recently,the results showed that kidney and liver fibrosis shared similar biological signals and events such as epithelialmesenchymal transition(EMT) and transforming growth factorβ1,the same herbal medicine exhibited significantly improving effects on both liver fibrosis and kidney fibrosis by involving similar mechanism.This coincides with the theory of homogeny of Liver(Gan) and Kidney(Shen) of Chinese medicine.It would provides new clues in exploring the treatment of liver fibrosis and kidney fibrosis. Chronic kidney disease (CKD) and chronic liver disease are both very harm to human health almost all over the world, which lead to the fibrosis of the two organs ultimately. Current there, there are few premonition therapeutic methods in treating the two diseases .Some research works from Chinese medicine and Western medicine were done in the area recently, the results showed that kidney and liver fibrosis shared similar biological signals and events such as epithelialmesenchymal transition (EMT) and transforming growth factor β1, the same herbal medicine show significantly improving effects on both liver fibrosis and kidney fibrosis by involving similar similar ..This coincides with the theory of homogeny of Liver (Gan) and Kidney (Shen) of Chinese medicine. It would provide new clues in exploring the treatment of liver fibrosis and kidney fibrosis.