论文部分内容阅读
根据三唑类抗真菌药物作用靶酶 -羊毛甾醇 14α 去甲基化酶的三维晶体结构和药物与酶活性位点的对接结果 ,设计合成了 11个 1 (1H 1,2 ,4 三唑 1 基 ) 2 (2 ,4 二氟苯基 ) 3 (N 甲基 N 取代苄基氨基 ) 2 丙醇化合物。 11个目标化合物均系首次报道。体外抗真菌活性试验结果表明 ,所有目标化合物对七种致病真菌都有不同程度的抗真菌活性 ,而且都比氟康唑的体外抗真菌活性好。化合物 11的抗菌谱最广 ,抗真菌活性最高 ,对新型隐球菌、白色念珠菌、羊毛状小孢子菌和红色毛癣菌的抗菌活性比酮康唑高 ,有进一步开发的价值。化合物 3,4,10也表现出较高的抗真菌活性
According to the three-dimensional crystal structure of the target enzyme-lanosterol 14α-demethylase and the docking results of the drug with the active site of the triazole azole antifungal drug, eleven 1 (1H 1,2, 4 triazole 1 Yl) 2 (2,4-difluorophenyl) 3 (N-methyl N-substituted benzylamino) 2 propanol compound. Eleven target compounds were first reported. In vitro antifungal activity test results show that all the target compounds have different degrees of antifungal activity to seven pathogenic fungi and are better than fluconazole in vitro antifungal activity. Compound 11 has the widest antimicrobial spectrum and the highest antifungal activity. It has higher antibacterial activity against Cryptococcus neoformans, Candida albicans, Microsporum sp. And Trichophyton rubrum than Ketoconazole, and has further development value. Compounds 3, 4, 10 also showed higher antifungal activity