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Smad通路是转化生长因子(TGF)-β超家族包括骨形态发生蛋白(BMP)信号转导的经典通路。Smad复合物的积聚导致其基因转录的过度活化,因此Smad的降解对Smad通路的调控至关重要。遍在蛋白-蛋白水解酶复合体通路降解Smad,对调控TGF-β信号转导发挥重要的调节作用。遍在蛋白-蛋白连接酶(Smurf)作为这一系统的核心,参与调控BMP和TGF-β两个家族的分子信号转导过程。本文就TGF-β/Smad通路、遍在蛋白酶体途径、遍在蛋白-蛋白连接酶Smurf家族及其结构、遍在蛋白-蛋白连接酶Smurf-1对Smad信号通路的调节等研究进展作一综述。
The Smad pathway is the classical pathway of the transforming growth factor (TGF) -β superfamily, including bone morphogenic protein (BMP) signaling. The accumulation of Smad complex leads to over-activation of its gene transcription, so the degradation of Smad is crucial for the regulation of Smad pathway. The ubiquitin-proteasome pathway degrades Smad and plays an important regulatory role in the regulation of TGF-β signaling. As the core of this system, ubiquitin-protein ligase (Smurf) is involved in the regulation of molecular signaling in both the BMP and TGF-β families. This review summarizes the progress in the regulation of the Smad signaling pathway by the TGF-β / Smad pathway, the ubiquitin pathway, the ubiquitin-protein ligase Smurf family and its structure, and the ubiquitin-protein ligase Smurf-1 .