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目的探讨核仁组织区嗜银蛋白（ＡｇＮＯＲ）染色技术在胃癌、癌前病变、慢性胃炎中鉴别诊断价值和意义。方法应用ＡｇＮＯＲ染色技术，观察１３２例胃良恶性病变和癌前病变细胞核中ＡｇＮＯＲ颗粒含量和形态。结果胃癌、胃粘膜异型增生、慢性胃炎三组间细胞核内ＡｇＮＯＲ颗粒均数差异非常显著（Ｐ＜０．０１），正常胃壁粘膜与慢性胃炎ＡｇＮＯＲ颗粒均数无明显差异（Ｐ＞０．０５）。胃癌和胃粘膜异型增生ＡｇＮＯＲ颗粒形态以弥散型为主，而慢性胃炎和正常胃粘膜以核仁型为主。结论细胞核内ＡｇＮＯＲ颗粒含量和分型对于区别胃良恶性及癌前病变有重要参考价值。
Objective To investigate the differential diagnostic value and significance of AgNOR staining technique in gastric cancer, precancerous lesions and chronic gastritis. Methods AgNOR staining technique was used to observe the content and morphology of AgNOR particles in 132 cases of benign and malignant lesions and precancerous lesions. Results There was a significant difference in the number of AgNOR particles in the nucleus between gastric cancer, gastric dysplasia, and chronic gastritis (P<0.01). There was no significant difference in the mean number of AgNOR granules between normal gastric mucosa and chronic gastritis (P>0.05). . The pattern of AgNOR granules in gastric cancer and dysplasia of gastric mucosa was mainly diffuse, while chronic gastritis and normal gastric mucosa were mainly nucleoli. Conclusion AgNOR granule content and typing in nucleus have important reference value for distinguishing benign from malignant and precancerous lesions.