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Survivin是新近发现的凋亡抑制蛋白IAP家族独特成员 ,具有抑制细胞凋亡和调节细胞分裂的双重功能 ,高表达于多种肿瘤组织而在正常成人组织中一般不表达或低表达。Survivin在肺癌中高表达 ,与肺癌的演进复发、预后差、药物耐药及病人生存率低有关 ,可作为肺癌诊断、治疗的新靶点。
Survivin is a newly discovered unique member of the IAP family of apoptosis-inhibitory proteins with dual functions of inhibiting apoptosis and regulating cell division. Survivin is overexpressed in many tumor tissues but not in normal adult tissues. Survivin is highly expressed in lung cancer, which is associated with the recurrence of lung cancer, poor prognosis, drug resistance and low survival rate of patients, which may serve as a new target for the diagnosis and treatment of lung cancer.