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目的研究母乳对苯丙酮尿症患儿血苯丙氨酸值的影响,了解母乳喂养对苯丙酮尿症患儿治疗的影响。方法选取2012年1-12月经西北妇女儿童医院新生儿疾病筛查中心确诊为苯丙酮尿症的患儿为研究对象,除立即采用低苯丙氨酸饮食治疗外,根据是否用母乳喂养分为母乳喂养组(n=68)和配方奶喂养组(n=20),定期检测两组患儿血苯丙氨酸值及生长发育。结果母乳喂养组68例患儿中60例(88.24%)患儿平均血Phe值在正常范围,人工喂养组患儿平均血phe值正常的有13例(65.00%),两组正常率比较差异有统计学意义(χ~2=4.372,P<0.05)。两组患儿6月龄时的身高、体重比较差异无统计学意义(t=0.17和2.42,P>0.05)。两组患儿智力发育比较差异无统计学意义(t=2.70,P>0.05)。结论两种喂养方法对苯丙酮尿症患儿血苯丙氨酸的影响无明显差异,母乳喂养更利于苯丙酮尿症患儿血phe值的控制。
Objective To study the effect of breast milk on the phenylalanine value in children with phenylketonuria and to understand the effect of breast-feeding on the treatment of children with phenylketonuria. Methods From January to December 2012, children diagnosed as phenylketonuria by the Neonatal Screening Center of Northwest Women and Children’s Hospital were enrolled. Subjects were treated with low-phenylalanine diet immediately and were divided according to whether they were breastfeeding Breastfeeding group (n = 68) and formula feeding group (n = 20), blood phenylalanine value and growth and development were detected regularly in both groups. Results The mean blood Phe values of 60 infants (88.24%) in the breastfeeding group were within the normal range. The average blood phe values in the artificial feeding group were 13 (65.00%), the normal rates were significantly different There was statistical significance (χ ~ 2 = 4.372, P <0.05). There was no significant difference in height and weight between the two groups at 6 months of age (t = 0.17 and 2.42, P> 0.05). There was no significant difference in mental development between the two groups (t = 2.70, P> 0.05). Conclusion There is no significant difference between the two feeding methods on phenylalanine in children with phenylketonuria. Breastfeeding is more conducive to the control of blood phe in children with phenylketonuria.