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目的观察双腔中心静脉(PICC)导管胸穿引流并羟基喜树碱联合白介素-2序贯注射治疗恶性胸水的临床疗效及相关毒副反应。方法全部患者均经双腔PICC管行胸腔闭式引流,引流至胸水近乎消失后注入药物,于d1、d3、d5注入HCPT30ml,d2、d4注入IL-2200万单位,10天一个周期,连续3个周期。结果共收治38例恶性胸水患者,按WHO胸水疗效标准规定,有效率达89.5%,毒副反应以轻度骨髓抑制和白细胞下降为主。结论双腔PICC导管胸穿引流并HCPT+IL-2序贯注射是治疗恶性胸水的有效方法,且毒副反应轻微。
Objective To observe the curative effect and related toxicities of PICC catheters in the treatment of malignant hydrothorax with thoracic drainage and sequential injection of hydroxycamptothecin and interleukin-2. Methods All patients underwent bilateral thoracic drainage with double-lumen PICC tube. After drainage, the drug was injected into the pleural fluid to almost disappear. Thirty ml of HCPT was injected into d1, d3 and d5. IL-22 million was injected into d2 and d4 for 10 days. A cycle. Results A total of 38 cases of malignant pleural effusion were treated. According to WHO criteria for pleural effusion, the effective rate was 89.5%. Toxic side effects were mild myelosuppression and leukopenia. Conclusion The double-lumen PICC catheter with chest drainage and sequential injection of HCPT + IL-2 is an effective method for the treatment of malignant pleural effusion with mild toxicity.