Applications of sediment transport and water flow characteristics based sediment transport simulation models for a river system are presented in this study.An existing water-sediment model and a new sediment-water model are used to formulate the simulation models representing water and sediment movement in a river system.The sediment-water model parameters account for water flow characteristics embodying sediment transport properties of a section.The models are revised formulations of the multiple water inflows model describing water movement through a river system as given by the Muskingum principle.The models are applied to a river system in Mississippi River basin to estimate downstream sediment concentration,sediment discharge,and water discharge.River system and the river section parameters are estimated using a revised and the original multiple water inflows models by applying the genetic algorithm.The models estimate downstream sediment transport rates on the basis of upstream sediment/water flow rates to a system.Model performance is evaluated by using standard statistical criteria;downstream water discharge resulting from the original multiple water inflows model using the estimated river system parameters indicate that the revised models satisfactorily describe water movement through a river system.Results obtained in the study demonstrate the applicability of the sediment transport and water flow characteristics-based simulation models in predicting downstream sediment transport and water flow rates in a river system. Applications of sediment transport and water flow characteristics based sediment transport simulation models for a river system are presented in this study. An existing water-sediment model and a new sediment-water model are used to formulate the simulation models representing water and sediment movement in a river system. sediment-water model parameters account for water flow characteristics embodying sediment transport properties of a section. The models are revised formulations of the multiple water inflows model describing water movement through a river system as given by the Muskingum principle. The models are applied to a river system in Mississippi River basin to estimate downstream sediment concentration, sediment discharge, and water discharge. River system and the river section parameters are estimated using a revised and the original multiple water inflows models by applying the genetic algorithm. The models estimate downstream sediment transport rates on the basis of upstream s water discharge results from the original multiple water inflows model using the estimated river system parameters indicate that the revised models satisfactorily describe water movement through a river system. Results obtained in the study demonstrate the applicability of the sediment transport and water flow characteristics-based simulation models in predicting downstream sediment transport and water flow rates in a river system.