论文部分内容阅读
结扎大鼠冠状动脉前降支造成急性心肌梗塞（ＡＭＩ），观察在ＡＭＩ后心室重构早期３、７、１４ｄ心肌线粒体呼吸功能和电子传递组分的改变。结果表明：在心室重构早期，心肌线粒体呼吸Ⅳ态（Ｒ＿４）明显增高（Ｐ＜０．０２）；呼吸Ⅲ态（Ｒ＿３）、呼吸控制率（ＲＣＲ）、磷／氧比（Ｐ／Ｏ）、氧化磷酸化速率（ＯＰＲ）明显下降（Ｐ＜０．００１）；呼吸链电子传递组分显著降低（Ｐ＜０．０５或Ｐ＜０．０１）。提示：ＡＭＩ后心室重构早期心肌线粒体呼吸和氧化磷酸化功能明显受损，是ＡＭＩ后慢性心力衰竭的重要原因。
Acute myocardial infarction (AMI) was induced by ligation of the anterior descending coronary artery in rats, and the mitochondrial respiratory function and electron transport components were observed at 3, 7 and 14 days after AMI. The results showed that at the early stage of ventricular remodeling, the myocardial mitochondrial respiratory state Ⅳ (R_4) was significantly increased (P <0.02); the respiratory state (R_3), respiratory control rate (RCR), P / O ratio (P <0.001). The electron transport components of respiratory chain were significantly decreased (P <0.05 or P <0.01). It is suggested that myocardial mitochondrial respiration and oxidative phosphorylation in early stage of ventricular remodeling after AMI are obviously impaired, which is an important cause of chronic heart failure after AMI.