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目的探讨汉族人群β1肾上腺素能受体Gly389Arg多态性与原发性高血压的关系。方法采用聚合酶链反应-限制性长度片段多态性技术分析原发性高血压患者和正常人群β1肾上腺素能受体Gly389Arg多态性。结果高血压组Arg/Arg,Arg/Gly,Gly/Gly基因型频率分别为59.06%、35.09%、5.85%,正常对照组分别为43.55%、45.97%、10.48%;两组间三种基因型频率分布有统计学差异(χ2=7.420,P<0.05);高血压组Arg等位基因频率为76.61%,Gly等位基因频率为23.39%,正常对照组分别为66.53%、33.47%,两组间等位基因频率分布存在统计学差异(χ2=7.299,P<0.05);高血压组Arg纯合子基因型频率和Arg等位基因频率均明显高于对照组。结论β1肾上腺素能受体Gly389Arg多态性可能与原发性高血压发病有关。
Objective To investigate the relationship between β-adrenergic receptor Gly389Arg polymorphism and essential hypertension in Han population. Methods Polymerase chain reaction - restriction fragment length polymorphism was used to analyze the Gly389Arg polymorphism of β1 adrenergic receptor in essential hypertension and normal subjects. Results The frequencies of Arg / Arg, Arg / Gly and Gly / Gly genotypes in hypertension group were 59.06%, 35.09% and 5.85%, respectively, and those in normal control group were 43.55%, 45.97% and 10.48% (Χ2 = 7.420, P <0.05). The frequency of Arg allele in hypertension group was 76.61%, the frequency of Gly allele was 23.39%, and that in normal control group was 66.53% and 33.47%, respectively There was a significant difference in allele frequency distribution between two groups (χ2 = 7.299, P <0.05). The frequency of Arg homozygote and Arg allele in hypertension group were significantly higher than those in control group. Conclusion The Gly389Arg polymorphism of β1 adrenergic receptor may be related to the pathogenesis of essential hypertension.