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目的 :观察雷贝拉唑治疗消化性溃疡临床症状和抗H.pylori治疗方面的优势。方法 :选择100例近期胃镜下证实为消化性溃疡而且活检病理有H.pylori的病人随机分成两组 ,分别为雷贝拉唑组和奥美拉唑组 ,三联疗法一周 ,停药后一月及三月复查14C呼气试验。结果 :雷贝拉唑组的12小时、24小时、72小时的临床症状缓解率高于奥美拉唑组 ,差异有显著性(P<0.05)。一周抗H.pylori治疗 ,雷贝拉唑的H.pylori根除率与奥美拉唑组相比 ,差异无显著性 (P>0.05)。结论 :雷贝拉唑在快速缓解消化性溃疡症状优于奥美拉唑。而在一周抗H.pylori治疗两组无差异。
OBJECTIVE: To observe the clinical symptoms of rabeprazole in the treatment of peptic ulcer and the advantages of anti-H.pylori treatment. Methods: 100 cases of peptic ulcer confirmed by recent gastroscopy and biopsy were divided into two groups randomly: rabeprazole group and omeprazole group, triple therapy for one week, one month after drug withdrawal And March review of 14C breath test. Results: The remission rate of clinical symptoms in rabeprazole group was significantly higher than that in omeprazole group at 12 hours, 24 hours and 72 hours (P <0.05). One week anti-H.pylori treatment, rabeprazole H.pylori eradication rate compared with the omeprazole group, no significant difference (P> 0.05). Conclusion: Rabeprazole is superior to omeprazole in relieving peptic ulcer rapidly. There was no difference between the two groups in anti-H.pylori treatment in one week.