在对数种生药的甲醇提取物筛选有效成分时发现,虎杖(Polygonum cuspidatum)及药用大黄(Rheum officinalis)提取物有强活性,并且发现了大黄素等蒽醌成分。为了明确蒽醌类的雌激素样活性的构效关系,对各种衍生物的活性进行了探讨。 实验与结果:观察虎杖、好望角芦荟、 When the active ingredients of several crude drug methanol extracts were screened, Polygonum cuspidatum and Rheum officinalis extracts were found to have strong activity, and glycosides such as emodin were found. In order to clarify the structure-activity relationship of terpenoid estrogenic activity, the activities of various derivatives were investigated. Experiments and results: Observe Polygonum cuspidatum, Aloe vera,