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头孢三嗪是一个广谱长效头孢菌素,临床用于肺部、胆道和尿道感染以及心内膜炎、柔脑膜炎和淋球菌感染。该药主要通过肾脏排出,10%-15%药物排入胆汁。在狗和猴大剂量和长时间用药的耐受性试验中,发现一些动物的胆囊中有沉淀物。1986-1988年连续报道头孢三嗪临床治疗中有的患者胆囊中有短暂的胆石形成,停药后随即消失。本文报道头孢三嗪治疗后6和12个月的长时间后的胆石情况。并与羟氨苄青霉素/克拉维酸组相比较。100例中74例可供评价,主要为尿道感染(51%)、肺部感染(16%)、耳
Ceftriaxone is a broad-spectrum long-acting cephalosporin that is clinically used in pulmonary, biliary and urinary tract infections, as well as endocarditis, meningococcal and gonococcal infections. The drug is mainly excreted through the kidneys, 10% -15% of the drug is discharged into the bile. In the tolerated trials of high dose and prolonged drug use in dogs and monkeys, some animals have found deposits in the gall bladder. 1986-1988 consecutive reports of ceftriaxone clinical treatment in patients with gallbladder in the brief transient gallstone formation, disappeared immediately after withdrawal. This article reports the duration of gallstone after 6 and 12 months of ceftriaxone treatment. And compared with amoxicillin / clavulanic acid group. Seventy-four of the 100 patients were eligible for evaluation, mainly urinary tract infections (51%), lung infections (16%), ears